Development of a 3D Printed Flow Cell for Application as an In-line Optical Particle Analysis Tool

Sebastian Soritz; Nico Nys; Matteo Thierrichter; Lorenz Buchgraber; Richard Amering; Peter Neugebauer; Heidrun Gruber-Woelfler

doi:10.1021/acs.oprd.4c00168

Development of a 3D Printed Flow Cell for Application as an In-line Optical Particle Analysis Tool

Sebastian Soritz^*, Nico Nys, Matteo Thierrichter, Lorenz Buchgraber, Richard Amering, Peter Neugebauer, Heidrun Gruber-Woelfler

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The demand for a cost-effective in-line particle measurement device is high, and the image analysis of particles in flow represents a promising concept to meet these expectations. In this work, we present an in-house developed image analysis flow cell to track particle size distributions in a process stream, including the necessary code and printing files for open-source use. For benchmarking of the flow cell, premade seeded solutions were prepared and analyzed by comparing the results to already applied and commercially available particle measurement devices. Furthermore, the results of six mixed-suspension, mixed-product-removal crystallization experiments were evaluated with the new measurement system.

Original language	English
Pages (from-to)	3940-3949
Number of pages	10
Journal	Organic Process Research and Development
Volume	28
Issue number	11
DOIs	https://doi.org/10.1021/acs.oprd.4c00168
Publication status	Published - 15 Nov 2024

Keywords

3D-printing
continuous crystallization
image analysis
rapid prototyping

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/acs.oprd.4c00168Licence: CC BY 4.0

Cite this

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title = "Development of a 3D Printed Flow Cell for Application as an In-line Optical Particle Analysis Tool",

abstract = "The demand for a cost-effective in-line particle measurement device is high, and the image analysis of particles in flow represents a promising concept to meet these expectations. In this work, we present an in-house developed image analysis flow cell to track particle size distributions in a process stream, including the necessary code and printing files for open-source use. For benchmarking of the flow cell, premade seeded solutions were prepared and analyzed by comparing the results to already applied and commercially available particle measurement devices. Furthermore, the results of six mixed-suspension, mixed-product-removal crystallization experiments were evaluated with the new measurement system.",

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AU - Amering, Richard

AU - Neugebauer, Peter

AU - Gruber-Woelfler, Heidrun

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AB - The demand for a cost-effective in-line particle measurement device is high, and the image analysis of particles in flow represents a promising concept to meet these expectations. In this work, we present an in-house developed image analysis flow cell to track particle size distributions in a process stream, including the necessary code and printing files for open-source use. For benchmarking of the flow cell, premade seeded solutions were prepared and analyzed by comparing the results to already applied and commercially available particle measurement devices. Furthermore, the results of six mixed-suspension, mixed-product-removal crystallization experiments were evaluated with the new measurement system.

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Development of a 3D Printed Flow Cell for Application as an In-line Optical Particle Analysis Tool

Abstract

Keywords

ASJC Scopus subject areas

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